Signal Transduction Mechanisms in Mesenchymal Cells
نویسندگان
چکیده
منابع مشابه
Mechanisms of Cellular Signal Transduction
Editorial Signal transduction is essential for almost all aspects of eukaryotic cell function and for the development of metazoans. In the classic case of signaling mediated by a growth factor, binding of the hormone to its receptor initiates a process that starts with the autoor cross-phosphorylation of the receptor. The activating signal is then propagated through intracellular signaling path...
متن کاملMechanisms of inhibin signal transduction.
Inhibin was first identified as a gonadal hormone that potently inhibits pituitary follicle-stimulating hormone (FSH) synthesis and secretion. Although the notion of a nonsteroidal, gonadally derived inhibitory substance was realized in the early 1930s (McCullagh, 1932), identification of the hormone was not accomplished until more than 50 years later. At that time, inhibin was purified from bo...
متن کاملAllosteric mechanisms of signal transduction.
Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation.
متن کاملMolecular mechanisms in signal transduction and cancer.
Introduction Good weather and a pint of apple juice (although we thought we had ordered beer) at a farmhouse opposite the European Molecular Biology Laboratory (EMBL) heralded the start of the 15th conference on ‘Oncogenes & Growth Control’. The participants had the opportunity to enjoy the friendly atmosphere at the EMBL, the hospitality of the staff and the tasty food. And of course, a series...
متن کاملMultisite Mechanisms for Ultrasensitivity in Signal Transduction
One of the key aspects in the study of cellular communication is understanding how cells receive a continuous input and transform it into a discrete, all-or-none output. Such so-called ultrasensitive dose responses can also be used in a variety of other contexts, from the efficient transport of oxygen in the blood to the regulation of the cell cycle and gene expression. This chapter provides a ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Critical Reviews in Oral Biology & Medicine
سال: 1994
ISSN: 1045-4411,1544-1113
DOI: 10.1177/10454411940050030501